Symbol
Name
ID

Ciita
class II transactivator
MGI:108445

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Agammaglobulinemia	Panhypogammaglobulinemia	Cutaneous anergy	Hemolytic anemia	Neutropenia	Leukopenia	Thrombocytopenia	Elevated erythrocyte sedimentation rate
Disease(s) Associated with CIITA	Agammaglobulinemia	Panhypogammaglobulinemia	Cutaneous anergy	Hemolytic anemia	Neutropenia	Leukopenia	Thrombocytopenia	Elevated erythrocyte sedimentation rate
MHC class II deficiency
rheumatoid arthritis
systemic lupus erythematosus

Mouse Phenotypes

decreased T cell proliferation

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-positive T cell number

decreased dendritic cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased osteoclast cell number

abnormal lymphocyte physiology

abnormal B cell physiology

abnormal immunoglobulin level

decreased IgG level

increased IgM level

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal MHC II cell surface expression on macrophages

Availability

Mouse Genotype

Ciita^m1Btlr/Ciita^m1Btlr

Ciita^tm1.1Dim/Ciita^tm1.1Dim

Ciita^tm1Ccum/Ciita^tm1Ccum

Ciita^tm1Jpyt/Ciita^tm1Jpyt

Ciita^tm1Wrth/Ciita^tm1Wrth

Ciita^tm2Wrth/Ciita^tm2Wrth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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